When the causal mutation is known, the challenge shifts from identifying disease origins to defining its detectable beginning ...

Register studies (Wimberly et al ) reveal the long-lasting educational disadvantage of childhood epilepsy but unexpected sex ...

Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery.

Objective This was a post hoc analysis of the Edaravone Phase III Study MCI186-19 (‘Study 19’) to examine the utility of clinical staging systems as end points in clinical trials in amyotrophic ...

Department of Neurology, Walton Centre for Neurology and Neurosurgery, Rice Lane, Liverpool, UK Dr PRD Humphrey, Department of Neurology, Walton Centre for Neurology and Neurosurgery, Rice Lane, ...

Background Cerebellar ataxias are the result of diverse disease processes that can be genetic or acquired. Establishing a diagnosis requires a methodical approach with expert clinical evaluation and ...

Department of Psychology, Institute of Psychiatry, Kings College, London, UK Correspondence to: Dr E Watkins, Department of Psychology, Institute of Psychiatry, De Crespingny Park, Denmark Hill, ...

Dr E H Reynolds, Institute of Epileptology, Weston Education Centre, King's College, Denmark Hill Campus, London SE5 9PJ, UK reynolds{at}buckles.u-net.com Present address for T Bottiglieri Institute ...

Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK Background: Detailed studies of mortality in multiple sclerosis (MS) are limited.

The main clinical features of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy) are stroke, dementia, and migraine. A reversible acute encephalopathy ...

OBJECTIVES Postural tremor is a regularly encountered side effect of amitriptyline which can be strong enough to cause discontinuation of therapy. The aim was to characterise amitriptyline induced ...