Translation initiation in eukaryotes is a complex and highly regulated process during which several initiation factors cooperate to recruit an initiator tRNA to the small ribosomal subunit, where ...

This pair of Hot Papers gave scientists a first-time, atomic-resolution view of the large ribosomal subunit and a mechanism to relate its atomic structure to its function. 1,2 "Many of the biochemical ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription and translation processes.

Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active regulator of gene expression at the level of protein biosynthesis. This ...

This study provides novel insights into the elongation dynamics of eukaryotic cells and the counteracting mechanisms in place to reduce translation defects during protein synthesis.

The Nsp1 NTD and linker regions are observed in a large number of interactions with ribosomal S3 (uS3). B) 40S subunit (pdb 6zlw) proteins interacting with Nsp1 highlighted in gold.