In Saccharomyces cerevisiae, acetylation of the Sir3 N terminus is important for transcriptional silencing. This covalent modification promotes the binding of the Sir3 BAH domain to the nucleosome, ...
Silent information regulator (SIR) proteins belong to a family of chromatin-regulatory factors, such as heterochromatin protein 1 and Polycomb, that are thought to function by folding the chromatin ...
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