Nature

Adipose tissue–derived MFG-E8 promotes hepatic inflammation and fibrosis through macrophage activation in a mouse MASH model

The worldwide prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD) and metabolic dysfunction–associated steatohepatitis (MASH) is estimated to be 38.0% and 5.27%, ...
Nature

Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p

Obesity increases the risk of depression. Evidence shows that peripheral inflammation, glycemic dysregulation, and hyperactivity within the hypothalamic-pituitary-adrenal axis are implicated in both ...
Medical Xpress

Specialized macrophages on adipose nerves curb age-related inflammation in mice

Yale School of Medicine-led research reports that nerve-associated macrophages help maintain healthy fat over a lifespan and curb age-related inflammation. Aging brings chronic low-grade inflammation ...
GEN

Potential New Obesity Target Found in Mitochondrial Protein Involved in Brown Fat Thermogenesis

Newly reported research in human tissue and in mice has uncovered a mechanism by which brown fat (brown adipose tissue; BAT) is converted into heat, and identified a control protein that may represent ...