In comparisons, consider lifestyles and evolutionary history of animals. Pancreas marks duodenum. Jejunum, ileum: attaches to large intestine and colon at a T junction with caecum or appendix.

Those transporters occurring more frequently in the distal jejunum and ileum may have less of an effect, if any, on drug absorption, since these segments are not surgically altered during RYGB.

For example, Mct1, UGT, PST, GST, and MRP2 distribution favors the duodenum and jejunum over the ileum. Rate of gastric emptying Slowed gastric emptying may reduce the rate of drug absorption ...