Chikungunya Virus: Pathophysiology, Mechanism, and Modeling
WEBDec 1, 2017 · Specifically, the virus is primarily transmitted by Aedes aegypti and Aedes albopictus. The principal vector in CHIKV transmission has historically been Ae. aegypti, but Ae. albopictus acted as the major vector in several recent outbreaks in Réunion, Europe, and Gabon [17], although Ae.
Structural and phenotypic analysis of Chikungunya virus
WEBSep 9, 2019 · Chikungunya virus (CHIKV) is a re-emerging, pathogenic Alphavirus transmitted to humans by Aedes spp. mosquitoes. We have mapped the RNA structure of the 5′ region of the CHIKV genome using selective 2′-hydroxyl acylation analysed by primer extension (SHAPE) to investigate intramolecular base-pairing at …
Molecular architecture of the Chikungunya virus replication …
WEBNov 30, 2022 · To better understand how positive-strand (+) RNA viruses assemble membrane-associated replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected cells, we determined both the high-resolution structure of the core RNA replicase of chikungunya virus and the native RC architecture in …
Chikungunya virus: epidemiology, replication, disease mechanisms…
WEBMar 1, 2017 · Chikungunya virus (CHIKV) is a mosquito-borne virus responsible for periodic and explosive outbreaks of a febrile disease that is characterized by severe and sometimes prolonged polyarthritis.
Biology and pathogenesis of chikungunya virus - Nature
WEBChikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region.
Structural and phenotypic analysis of Chikungunya virus RNA
WEBSep 26, 2019 · Chikungunya virus (CHIKV) is a re-emerging, pathogenic Alphavirus transmitted to humans by Aedes spp. mosquitoes. We have mapped the RNA structure of the 5' region of the CHIKV genome using selective 2'-hydroxyl acylation analysed by primer extension (SHAPE) to investigate intramolecular base-pairin ….
Chikungunya virus infection: molecular biology, clinical ...
WEBDec 2, 2021 · Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV first emerged in 1954.
Frontiers | Overview on Chikungunya Virus Infection: From …
WEBOct 5, 2021 · Introduction. Chikungunya virus (CHIKV) is an arthritogenic arbovirus from Togaviridae family and Alphavirus genus, which is responsible for recurring epidemics over the years worldwide (Mason and Haddow, 1957). CHIKV is considered an important public health problem because it is endemic in tropical and subtropical regions of the globe.
Functional and structural characterization of the chikungunya virus ...
WEBHere, we report the molecular and structural characterization of two CHIKV translational recoding signals: a termination codon read-through (TCR) element located between the nonstructural protein 3 and 4 genes and a programmed −1 ribosomal frameshift (−1 PRF) signal located toward the 3′ end of the CHIKV 6K gene.
Architecture of the chikungunya virus replication organelle
WEBOct 19, 2022 · Chikungunya virus is a very important human pathogen, and research on the architecture of its replication/transcription organelle holds great promise for the development of future therapies. Laurent and colleagues advanced this field by providing pioneering low-resolution 3D structures of the membrane …
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